The clock struck 162 million…and nothing changed

Our latest publication compared key immune checkpointmolecules in nine different species ranging from humans to mice to bats to Tasmanian devils. Despite the last common ancestor of marsupial and placental animals occurring 162,000,000 years ago, we found a remarkable level of similarity in key regions for these critical immune molecules. This suggests that some immunotherapy or vaccine approaches that work in humans might also work in Tasmanian devils!

Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease

This is a technical and jargon-rich manuscript, but has the most interesting immunological insight of any Wild Immunity paper to date!

 

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