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Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils

A new research paper shows evidence that immunization with devil facial tumor cells plus adjuvants (i.e. immune stimulators) primes anti-tumor immune responses. Subsequent booster shots with live tumor cells induced tumor regressions in 3/5 devils.

The first Wild Immunity article about our checkpoint molecule research in Tasmanian devils is published in The Conversation

Wild Immunity research about immune checkpoint molecules is published in Frontiers in Immunology

This new publication shows that the key immune checkpoint molecule PD-L1 (aka B7-H1) is upregulated on devil facial tumour cells in response to interferon-gamma (IFNg). This could be an important immune evasion mechanism used by the tumour to shut off anti-tumour responses by T cells and NK cells.

Wild Immunity research published in Functional Ecology is featured in Smithsonian magazine

Wild Immunity research published in Functional Ecology is featured in Smithsonian magazine.

Another contagious cancer discovered

How many more are out there? 

Check out the latest wild immunity research!

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PLOS ONE: Markedly Elevated Antibody Responses in Wild versus Captive Spotted Hyenas Show that Environmental and Ecological Factors Are Important Modulators of Immunity

Andrew S. Flies