Researcher ID profile: B-3122-2008

ORCID profile: 0000-0002-4550-1859

Loop profile: 378455

Impact story profile

Peer-reviewed publications

26) Flies AS, Darby JM, Lennard PR, Murphy PM, Ong CEB, Pinfold TL, Lyons AB, Woods GM, Patchett AL. (2019). A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers. bioRxiv. DOI: 10.1101/831404

25) Flies AS, Flies EJ, Fox S, Gilbert A, Johnson SR, Liu GS, Lyons AB, Patchett AL, Pemberton D, Pye RJ. An oral bait vaccination approach for the Tasmanian devil facial tumor diseases. Expert Rev. Vaccines. 2020;1–10. DOI: 10.1080/14760584.2020.1711058 Free PDF download (50 copies until they are gone)

24) Patchett AL, Flies AS, Lyons AB, Woods, GM. Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii). Cell. Mol. Life Sci. 2020; 1-19. DOI: 10.1007/s00018-019-03435-4

23) Patchett AL, Coorens THH, Darby JM, Wilson R, McKay MJ, Kamath KS, Rubin A, Wakefield M, Mcintosh L, Mangiola S, Pye RJ, Flies AS, Corcoran LM, Lyons AB, Woods GM, Murchison EP, Papenfuss AT, Tovar C. (2019). Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii). Cellular and Molecular Life Sciences. DOI: 10.1007/s00018-019-03259-2

22) Martin LB, Addison B, Bean AGD, Buchanan, KL, Crino OL, Eastwood JR, Flies AS, Hamede R, Hill GE, Klaasen M, Koch RE, Martens JM, Napolitano C, Narayan EJ, Peacock L, Peel AJ, Roast MJ, Rollins LA, Ruiz-Aravena M, Selechnik D, Stokes HS, Ujvari B, Grogan L. (2019). Extreme competence: keystone hosts of infection. Trends in Ecology and Evolution. DOI: 10.1016/j.tree.2018.12.009

21) Flies AS, Wood, GM. (2019). Wild Immunology – The answers are out there. Research Topic Editorial. Frontiers in Immunology. DOI: 10.3389/fimmu.2019.00126

20) Ong CEB, Lyons AB, Woods GM, Flies AS. (2019). Inducible IFN-γ expression for MHC-I upregulation in devil facial tumor cells. Frontiers in Immunology. DOI: 10.3389/fimmu.2018.03117

19) Woods GM, Fox S, Flies AS, Tovar CD, Jones M, Hamede R, Pemberton D, Lyons AB, Bettiol SS. (2018). Two decades of the impact of Tasmanian Devil Facial Tumour Disease (DFTD) (Review). DOI: 10.1093/icb/icy118

18) Flies, A.S., Blackburn, N., Lyons, A.B., Hayball, J.D., Woods, G.E. (2017). Comparative analysis of immune checkpoint molecules and their potential role in the transmissible Tasmanian devil facial tumor disease. DOI: 10.3389/FIMMU.2017.00513

17) Flies, A. S., Lyons, A. B., Corcoran, L. M., Papenfuss, A. T., Murphy, J. M., Knowles, G., W., Woods, G. M., Hayball, J. D. 2016. PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment. Frontiers in Immunology. DOI: 10.3389/fimmu.2016.00581

16) Flies, E. J., Flies, A. S., Weinstein, P., Williams, C. R. 2016. Regional Comparison of Mosquito Bloodmeals in South Australia: Implications for Ross River Virus Ecology. Journal of Medical Entomology. DOI: 10.1093/jme/tjw035

15) Flies, A. S., Mansfield, L. S., Johnston, E.S., Grant, C. K., and Holekamp, K. E. 2016. Socioecological predictors of immune defenses in a wild spotted hyenas. Functional Ecology. Volume 30, 1549-1557. DOI: 10.1111/1365-2435.12638

13) Flies, A. S., Mansfield, L. S., Grant, C. K., Weldele, M. L., and Holekamp, K. E. 2015. Markedly elevated antibody responses in wild versus captive spotted hyenas show that environmental and ecological factors are important modulators of immunity. PLoS ONE 10(10): e0137679. DOI: 10.1371/journal.pone.0137679

14) Luo, L., Zhu, G., Xu, H., Yao, S., Zhou, G., Zhu, Y., Tamada, K., Huang, L., Flies, A. S., Broadwater, M., Ruff, W., van Deursen, J. M. A., Melero, I., Zhu, Z., Chen, L. 2015. B7-H3 promotes pathogenesis of autoimmune disease and inflammation by regulating the activity of different t cell subsets. PLoS One. DOI: 10.1371/journal.pone.0130126

12) Flies, A. S., Maksimoski, M. T., Mansfield, L. S., and Holekamp, K. E. 2014. Characterization of toll-like receptors 1–10 in spotted hyenas. Veterinary Research Communications. DOI: 10.1007/s11259-014-9592-3

11) Johnston (Flies), E., Weinstein, P., Slaney, D., Flies, A. S., Williams, C.R. 2014. Mosquito communities with trap height and rural-urban gradient in Adelaide, South Australia: implications for disease vector surveillance. Journal of Vector Ecology. DOI: 10.1111/j.1948-7134.2014.12069.x

10) Nelson, K.G., Engh, A. L., McKnight, C. A., Kiupel, M, Wise, A G., Maes, R. K., Stevens, H, Heylen, E, De Keyser, K, Rector, A, Van Ranst, M, Flies, A. S., and Holekamp, Kay E. 2013.Papillomavirus-associated Cutaneous Papillomas in a Population of Wild Spotted Hyenas (Crocuta crocuta). Journal of Wildlife Diseases. 49, 620-627. DOI: 10.7589/2011-09-262

9) Flies, A. S., Grant, C. K., Mansfield, L. S., Smith, E. J., Weldele, M. and Holekamp, K. E. 2011.Development of a hyena immunology toolbox. Veterinary Immunology and Immunopathology. 145, 110-119, DOI: 10.1016/j.vetimm.2011.10.016

8) Zhu, G., Augustine, M. M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A. C., Huang, J., Xu, H., Flies, A. S., and Chen, L. 2009. B7-H4 deficient mice display augmented neutrophil-mediated innate immunity. Blood. 113:1759-1767. DOI: 10.1182/blood-2008-01-133223.

7) Azuma, T., Yao, S., Zhu, G., Flies, A. S., Flies, S. J. and Chen, L. 2008. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 111:3635-3643. DOI: 10.1182/blood-2007-11-123141

6) Goldberg, M. V., Maris, C. H., Hipkiss, E. L., Flies, A. S., Zhen, L., Tuder, R. M., Grosso, J. F., Harris, T. J., Getnet, D., Whartenby, K. A., Brockstedt, D. G., Dubensky, T. W., Chen, L., Pardoll, D. M. and Drake, C. G. 2007. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 110:186-192. DOI: 10.1182/blood-2006-12-062422

5) Tsushima, F., Yao, S., Shin, T., Flies, A. S., Flies, S., Xu, H., Tamada, K., Pardoll, D. and Chen, L. 2007. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 110:180. DOI: 10.1182/blood-2006-11-060087

4) Xu, Y., Flies, A. S., Flies, D. B., Zhu, G., Anand, S., Flies, S. J., Xu, H., Anders, R. A., Hancock, W. W., Chen, L. and Tamada, K. 2007. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109:4097-4104. DOI: 10.1182/blood-2006-09-047332

3) Zhu, Y., Zhu, G., Luo, L., Flies, A. S., and Chen, L. 2007. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 109:4882-4889. DOI: 10.1182/blood-2006-10-043463

2) Anand, S., Wang, P., Yoshimura, K., Choi, I., Hilliard, A., Chen, Y., Wang, C., Schulick, R., Flies, A. S. , Flies, D. and Chen, L. 2006. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. Journal of Clinical Investigation. 116:1045-1051. DOI: 10.1172/JCI27083

1) Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y. and Chen, L. 2004. B7-H3 Enhances Tumor Immunity In Vivo by Costimulating Rapid Clonal Expansion of Antigen-Specific CD8+ Cytolytic T Cells. The Journal of Immunology. 173:5445-5450. DOI: 10.4049/jimmunol.173.9.5445

Science-related media

Flies AS, Baker, ML, Le Nours, J, Rossjohn J. Response to “The future of humans as model organisms”. eLetter in Science.

Spotted hyenas rarely die from disease: we set out to discover why. 2017. The Conversation Africa

Deadly disease can ‘hide’ from a Tasmanian devil’s immune system. 2016. The Conversation Australia

Front page article in The Mercury:  New devil cancer hope (page 1 and continued on page 19). 2017. The Mercury

Notes from Kenya: MSU Hyena Research. 2006-2010. 

Interview in In Vitro Magazine. 2009.

MSU Alumni Magazine feature of the Hyena Research Project. 2009.

Disease Ecology and Immunology of the Spotted Hyena. 2007. The Vector