Publications

Peer-reviewed publications

18) Flies, A.S., Blackburn, N., Lyons, A.B., Hayball, J.D., Woods, G.E. (2017). Comparative analysis of immune checkpoint molecules and their potential role in the transmissible Tasmanian devil facial tumor disease. DOI: 10.3389/FIMMU.2017.00513

17) Flies, A. S., Lyons, A. B., Corcoran, L. M., Papenfuss, A. T., Murphy, J. M., Knowles, G., W., Woods, G. M., Hayball, J. D. 2016. PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment. Frontiers in Immunology. DOI: 10.3389/fimmu.2016.00581

16) Flies, E. J., Flies, A. S., Weinstein, P., Williams, C. R. 2016. Regional Comparison of Mosquito Bloodmeals in South Australia: Implications for Ross River Virus Ecology. Journal of Medical Entomology. DOI: 10.1093/jme/tjw035

15) Flies, A. S., Mansfield, L. S., Johnston, E.S., Grant, C. K., and Holekamp, K. E. 2015. Socioecological predictors of immune defenses in a wild spotted hyenas. Functional Ecology. Volume 30, 1549-1557. DOI: 10.1111/1365-2435.12638

14) Luo, L., Zhu, G., Xu, H., Yao, S., Zhou, G., Zhu, Y., Tamada, K., Huang, L., Flies, A. S., Broadwater, M., Ruff, W., van Deursen, J. M. A., Melero, I., Zhu, Z., Chen, L. 2015. B7-H3 promotes pathogenesis of autoimmune disease and inflammation by regulating the activity of different t cell subsets. PLoS One. DOI: 10.1371/journal.pone.0130126

13) Flies, A. S., Mansfield, L. S., Grant, C. K., Weldele, M. L., and Holekamp, K. E. 2015. Markedly elevated antibody responses in wild versus captive spotted hyenas show that environmental and ecological factors are important modulators of immunity. PLoS ONE 10(10): e0137679. DOI: 10.1371/journal.pone.0137679

12) Flies, A. S., Maksimoski, M. T., Mansfield, L. S., and Holekamp, K. E. 2014. Characterization of toll-like receptors 1–10 in spotted hyenas. Veterinary Research Communications. DOI: 10.1007/s11259-014-9592-3

11) Johnston (Flies), E., Weinstein, P., Slaney, D., Flies, A. S., Williams, C.R. 2014. Mosquito communities with trap height and rural-urban gradient in Adelaide, South Australia: implications for disease vector surveillance. Journal of Vector Ecology. DOI: 10.1111/j.1948-7134.2014.12069.x

10) Nelson, K.G., Engh, A. L., McKnight, C. A., Kiupel, M, Wise, A G., Maes, R. K., Stevens, H, Heylen, E, De Keyser, K, Rector, A, Van Ranst, M, Flies, A. S., and Holekamp, Kay E. 2013.Papillomavirus-associated Cutaneous Papillomas in a Population of Wild Spotted Hyenas (Crocuta crocuta). Journal of Wildlife Diseases. 49, 620-627. DOI: 10.7589/2011-09-262

9) Flies, A. S., Grant, C. K., Mansfield, L. S., Smith, E. J., Weldele, M. and Holekamp, K. E. 2011.Development of a hyena immunology toolbox. Veterinary Immunology and Immunopathology. 145, 110-119, DOI: 10.1016/j.vetimm.2011.10.016

8) Zhu, G., Augustine, M. M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A. C., Huang, J., Xu, H., Flies, A. S., and Chen, L. 2009. B7-H4 deficient mice display augmented neutrophil-mediated innate immunity. Blood. 113:1759-1767. DOI: 10.1182/blood-2008-01-133223.

7) Azuma, T., Yao, S., Zhu, G., Flies, A. S., Flies, S. J. and Chen, L. 2008. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 111:3635-3643. DOI: 10.1182/blood-2007-11-123141

6) Goldberg, M. V., Maris, C. H., Hipkiss, E. L., Flies, A. S., Zhen, L., Tuder, R. M., Grosso, J. F., Harris, T. J., Getnet, D., Whartenby, K. A., Brockstedt, D. G., Dubensky, T. W., Chen, L., Pardoll, D. M. and Drake, C. G. 2007. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 110:186-192. DOI: 10.1182/blood-2006-12-062422

5) Tsushima, F., Yao, S., Shin, T., Flies, A. S., Flies, S., Xu, H., Tamada, K., Pardoll, D. and Chen, L. 2007. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 110:180. DOI: 10.1182/blood-2006-11-060087

4) Xu, Y., Flies, A. S., Flies, D. B., Zhu, G., Anand, S., Flies, S. J., Xu, H., Anders, R. A., Hancock, W. W., Chen, L. and Tamada, K. 2007. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109:4097-4104. DOI: 10.1182/blood-2006-09-047332

3) Zhu, Y., Zhu, G., Luo, L., Flies, A. S., and Chen, L. 2007. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 109:4882-4889. DOI: 10.1182/blood-2006-10-043463

2) Anand, S., Wang, P., Yoshimura, K., Choi, I., Hilliard, A., Chen, Y., Wang, C., Schulick, R., Flies, A. S. , Flies, D. and Chen, L. 2006. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. Journal of Clinical Investigation. 116:1045-1051. DOI: 10.1172/JCI27083

1) Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y. and Chen, L. 2004. B7-H3 Enhances Tumor Immunity In Vivo by Costimulating Rapid Clonal Expansion of Antigen-Specific CD8+ Cytolytic T Cells. The Journal of Immunology. 173:5445-5450. DOI: 10.4049/jimmunol.173.9.5445

General interest media

Spotted hyenas rarely die from disease: we set out to discover why. 2017. The Conversation Africa

Deadly disease can ‘hide’ from a Tasmanian devil’s immune system. 2016. The Conversation Australia

Front page article in The Mercury:  New devil cancer hope (page 1 and continued on page 19). 2017. The Mercury

Notes from Kenya: MSU Hyena Research. 2006-2010. 

Interview in In Vitro Magazine. 2009.

MSU Alumni Magazine feature of the Hyena Research Project. 2009.

Disease Ecology and Immunology of the Spotted Hyena. 2007. The Vector